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Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier

Received: 19 September 2016     Published: 27 September 2016
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Abstract

Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.

Published in International Journal of Biomedical Science and Engineering (Volume 4, Issue 3)
DOI 10.11648/j.ijbse.20160403.13
Page(s) 28-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Nanocarrier, Chitosan Derivative, Drug Carrier

References
[1] A. Sathiyanarayanan, and M. Sathiyabama, “Induced chitinase and chitosanase activities in turmeric plants by application of β-D-glucan nanoparticles,” Notulae Scientia Biologicae , vol. 7, no. 3, pp. 295-298, 2015.
[2] M. A. Elgadir , M. S. Uddin, S. Ferdosh, A. Adam, A. J. K. Chowdhury and M. Z. I. Sarker, “Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review,” Journal of Food & Drug Analysis, vol. 23, no. 4, pp. 619-629, 2014.
[3] B. H. Feng and L. F. Peng, “Synthesis and characterization of carboxymethyl chitosan carrying ricinoleic functions as an emulsifier for azadirachtin,” Carbohydrate Polymers, vol. 88, no. 2, pp. 576–582, 2012.
[4] D. B. Shenoy and G. B. Sukhorukov. “Engineered microcrystals for direct surface modification with layer-by-layer technique for optimized dissolution,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no.3, pp. 521-527, 2004.
[5] A. Kamari, N. F. A. Aljafree and S. N. M. Yusoff, “Oleoyl-carboxymethyl chitosan as a new carrier agent for the rotenone pesticide,” Environmental Chemistry Letters, vol. 14, no. 3, pp. 417-422, 2016.
[6] Y. K. Wu, J. Lin and M.Ye, “Determination of Rotenone by High Performance Liquid Chromatography,” Yunnan Chemical Technology, vol. 33, no. 2, pp. 59-60, 2006.
[7] X. H. He and F, Schmid, “Spontaneous formation of complex micelles from a homogeneous solution,” Physical review letters, vol. 100, no. 13, pp. 137802. 2007
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  • APA Style

    Bohua Feng, Liufen Peng. (2016). Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. International Journal of Biomedical Science and Engineering, 4(3), 28-33. https://doi.org/10.11648/j.ijbse.20160403.13

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    ACS Style

    Bohua Feng; Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int. J. Biomed. Sci. Eng. 2016, 4(3), 28-33. doi: 10.11648/j.ijbse.20160403.13

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    AMA Style

    Bohua Feng, Liufen Peng. Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier. Int J Biomed Sci Eng. 2016;4(3):28-33. doi: 10.11648/j.ijbse.20160403.13

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  • @article{10.11648/j.ijbse.20160403.13,
      author = {Bohua Feng and Liufen Peng},
      title = {Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier},
      journal = {International Journal of Biomedical Science and Engineering},
      volume = {4},
      number = {3},
      pages = {28-33},
      doi = {10.11648/j.ijbse.20160403.13},
      url = {https://doi.org/10.11648/j.ijbse.20160403.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20160403.13},
      abstract = {Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Preparation on Chitosan Derivative Nanoparticles as Prolonged Releasing Drug Carrier
    AU  - Bohua Feng
    AU  - Liufen Peng
    Y1  - 2016/09/27
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijbse.20160403.13
    DO  - 10.11648/j.ijbse.20160403.13
    T2  - International Journal of Biomedical Science and Engineering
    JF  - International Journal of Biomedical Science and Engineering
    JO  - International Journal of Biomedical Science and Engineering
    SP  - 28
    EP  - 33
    PB  - Science Publishing Group
    SN  - 2376-7235
    UR  - https://doi.org/10.11648/j.ijbse.20160403.13
    AB  - Ricinoleic acid grafted amphiphilic carboxymethy chitosan (CMC-g-RA) was synthetised as a carrier to load botanical drug rotenone (Rot). Then Rot/CMC-g-RA water dispersion in nanoscale was prepared, whose shape, zeta potential, loading efficiency and outdoor stability were characterized accordingly. The results indicated that the sizes, polydispersity index, zeta potential of Rot/CMC-g-RA particles were affected by concentrations of this water dispersion. When the ratio of carrier to drug ascended, the water dispersion had monodisperse nanoparticle sizes with negative charge on nanoparticle surface. And the water dispersion restrained Rot degradation in natural environment with higher loading efficiency.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, P. R. China

  • College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, P. R. China

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